Sometime in the near future, paraplegic prison inmate Matt Mills meets The Board of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.

帕特里克昏昏欲睡在一家小型私立医院，他唯一的举动是非自愿地随地吐痰。当一个刚与丈夫分开的年轻护士开始在医院工作时，她感觉到帕特里克正在与她交流，他似乎正在利用自己的心理力量来操纵她生活中的事件。凯西是一名年轻的护士，她渴望在一家偏僻的精神病诊所的新工作中证明自己。她对帕特里克很感兴趣，帕特里克是一名昏迷的病人，她的老板罗杰特医生向她保证，帕特里克无法对任何外部刺激做出真正的反应。凯西对罗杰特和他的护士卡西迪护士长对他进行的实验感到震惊，当她找到一种与他交流的方法时，她最初很高兴。当帕特里克利用他的通灵能力干扰她在医院外的生活时，这很快就变成了恐怖，因为帕特里克对凯西越来越着迷，并且会伤害任何他认为干扰他与她关系的人。在一家私人诊所，一名年轻护士很快发现一名昏迷的病人相当险恶。当一名年轻护士开始在一个偏僻的精神病房工作时，她很快就对帕特里克产生了兴趣，帕特里克是一名脑死亡患者，也是一位疯狂科学家残酷而不寻常的实验的对象。当帕特里克开始利用他的心灵力量操纵她的一举一动，并使她的生活陷入失控的可怕螺旋时，最初的无辜迷恋很快就发生了险恶的转变。